Parkinson’s Disease

It’s estimated that over 1 million people in the United States live with Parkinson’s Disease and more than 10 million people worldwide. The occurrence of the disease parallels the increased usage of glyphosates and genetically modified food. Parkinson’s disease, PD, is the result of a severe decrease of dopamine production by the substantia nigra of the basal ganglia, located in the brain stem. Research shows this is a result of mitochondria and cellular DNA dysfunction.

The symptoms of PD are initially decreased by dosages of oral dopamine. Dopamine replacement is currently considered the preferred treatment of PD. Some patients have increase symptoms with the use of dopamine and others have an increase in a decline of health from supplemental dopamine. Is there another underlying cause of the PD that could be occurring that is being missed or overlooked?

Fig. 1. The prevalence of Parkinson’s disease in the United States

Parkinson’s Disease, PD, is a progressive neurodegenerative disease associated with a decreased production of dopamine, DA, by the substantia nigra, SN, located in the brain stem; and is characterized by tremor, unsteady gait, and weakness. The substantia nigra is the site of dopamine production and metabolism. The regional neuronal cells are highly concentrated in dopamine. A misdirection in the dopamine metabolic pathway can form the dopamine-quinone, DA-Q, which significantly compromises the neurons of the substantia nigra (in the brain stem) region with an intense localized oxidative stress. This causes cellular DNA damage and mitochondrial dysfunction resulting in decreased ATP (the energy currency of life) production leading to the symptoms of Parkinson’s. Collectively, the research shows that an objective treatment of Parkinson’s disease can reduce the presence of the dopamine-quinone and significant oxidation stress through a change to a favorable cellular environment. This in combination with proper dopamine precursors could lead to neuroplasticity (changes in the brain) resulting in regaining dopamine production by the substantia nigra neurons.

The functional medicine treatment for Parkinson ’s disease is always based on stopping the progression of the disease. As the rate of progression is reducing the repair in the fault of the metabolism that leads to the disease process can begin. Finally, to encourage neuron growth and dopamine production based on the principles of neuroplasticity (change in the brain) and brain-derived neurotrophic factor (growth factors that signal particular cells to survive, differentiate, or grow.)

Case Study

‘Tom’ is an 80-year-old professional white male diagnosed one year before PD. He presents with a persistent tremor, weak and unsteady stance and gait. He is concerned by the rapidly progressive changes and is under treatment with medication, levodopa, and carbidopa. When he started taking the medication, one year ago, there was an improvement in his symptoms. This enhancement lasts for a short time and has now turned from improvement to worsening of the symptoms. He is right hand dominant, and the unsteadiness of the right-hand hinders his writing ability. History of impotence.

He takes no other medication and has no known allergies to medication. His blood pressure runs high in office, 179/81, and normal at home, 135/70. Pulse, 60 +/-, is regular and strong at both office and home. Resting respiratory is non-labored with rate 18 breaths per minute.

Physically, ‘Tom’ shows no sign of cognizant decline and is articulate in thought and speech. He has a persistent tremor of both hands, with the right more severe than the left. Right-hand tremor intensifies with deliberate movement. The right-hand grip is weak as is his overall muscular strength. Cardiovascularly is unremarkable. Other than the above description, he is neuro-vascular intact. Abdomen, with bloating and increase tympany (heard if heard if distended with gas), without tenderness. Halitosis (bad breath) is present.

Diet is the Standard American Diet with an aversion to vegetables.‘Tom’ was evaluated by Functional Medicine Nutritionist, who utilizes a specialized bio-feedback device. The Dietician’s evaluation and modification included:• A Paleolithic alkalized diet with therapeutic protein shakes plus digestive enzymes.• Supplements to include N-acetyl Cysteine, Resveratrol, Phenylalanine, Vitamin B’s, RNA/methylation drops (homeopathic) phosphine liquid, glutamine, CoQ10, Vitamin D, and candida supplements.

‘Tom’ treatment began with diet changes, as per the above the diet and supplement recommendations, plus SAMe and zinc carnosine. ‘Tom’s’ treatments included an intravenous vitamin/mineral/amino acid solution followed by glutathione. Hormonal treatment will begin after 1-month of the above treatment.

​Within one week of the above treatment, the tremor decreased accompanied by increase strength and steadiness.
At six weeks of treatment, ‘Tom’s’ strength, gait, and stability have dramatically improved. The tremor is rare and unnoticeable. He can write legibly. He does take one tablet of the L-Dopa occasionally yet does not have any adverse reaction. His labs done after 6 weeks showed a remarkable turnaround.

The next steps are to increase regeneration of the SN neurons and dopamine production, as outlined above. “Tom’, his familyand the medical staff were extremely happy with his results so far and looked forward to the future progress.

Lyme Disease

As a Lyme literate physician, Dr Muran has been treating Lyme recovery for 15 years collaborating with Drs. Ray Jones, Ray Stricker, Joseph Jemsek and Richard Horowitz. As appears in Insights into Lyme Disease Treatment, the functional medicine approach uncovers the reasons for prior failures in treatment. Simply stated, the need to optimize the health of the body while eradicating the disease. Our practice is very active with the joys of success.

The Lyme disease’s challenge stems from Borrelia burgdorferi (Bb); a moving target with its multiple forms contributing to an amazing defense mechanism. It is the multiple changing of forms which permits the bacteria to be undetected by the immune system and untreated by certain antibiotic regimens. In an unstressed environment, Bb appears as an active spirochete with a cell wall. When environmentally stressed, it will change to a cystic form without a cell wall yet is surrounded by a protective biofilm. At a higher environmental stress level, Bb will invade the host’s cells and live as intracellular parasite. It can sustain itself in this intracellular state for 3 to 4 months. In thisintracellular form, it is completely concealed from the immune system and can return to the active spirochete form in a favorable environment.

Knowing these changes in morphology guides treatment changes that conform to the presentation and eradication of the disease. After obtaining a full and concise history and physical exam, the patient’s treatment is managed utilizing a functional medicine approach. The labs are used as guidelines to the treatment.

The treatment for Lyme disease could start out as oral antibiotics, or progress to the use of intravenous antibiotics or colloidal silver. During the whole course of treatment, the patient is supported to optimize strength and energy. The treatment GOAL is to strengthen the immune system enabling progression from antibiotics to supportive, friendly to the body, treatment with fewer side effects. As you will see, Lyme disease is not Lyme Disease

Hormone Replacement Therapy, BHRT

Our goal at Longevity Healthcare is to improve your health and happiness, which in some instances requires personalized hormone balancing and/or replacement. Our hormone program will deliver better quality of life and improved sense of well-being that you’llenjoy. In all instances, a thorough assessment to address the specific needs are based on the patient’s presentations.


The human body makes about 50 hormones. Some are more crucial for life than others. Cortisol, insulin and thyroid are hormones that are of higher life preserving need than estrogen and testosterone. As the science goes, if the body needs cortisol the brain will stop making the messaging hormone to testicle and ovaries decreasing the production of testosterone and estrogen. Subsequently, if the signaling for cortisol production is reduced then the production of testosterone and estrogen will increase.


In a similar manner insulin and glucose play a major role in metabolism and overall health of every cell in your body. This does not reduce the need for testosterone and estrogen, for these hormones help to strengthen the body and mind while keeping insulin resistance in balance.

Our patients have great results with hormone balancing and replacement because the whole hormonal profile is managed and optimize. For instance, many men are readily prescribed testosterone without looking at the more complicated profile. The result of this over-prescribing can result in testicular atrophy, shrinkage of the testicle, which could increase the problem in testosterone production. The management of andropause in our male patients helps us see if the testicles can produce an increase in testosterone on their own, which is a higher level of care then a pellet or cream. If they cannot produce sufficient levels of their own testosterone or request testosterone supplement then bioidentical testosterone is prescribed.

Women are relieved by our concern for the development of breast disease and the in-depth understanding of estrogen metabolism. We answer the question that if estrogen causes cancer then why does breast cancer occur when the women are in their 50/60’s and not in their 20/30’s when the estrogen is the lowest versus highest, respectively. We have the answer and the tools; see videos below.


All of our patients are informed to the benefits and drawbacks of the various treatment protocols for both men and women by choosing several different hormone vehicles and application modes –based on titration, physical evaluation and laboratory testing. Various testing methods are utilizing to optimize the understanding and implementing the most effective hormonal replacement necessary.


The BHRT administered are either small pellets, topical creams, oral and sublingual preparations or vaginal preparations.

The Difference between Functional and Conventional Medicine

The difference between Functional Medicine and Conventional Medicine, the best way to explain it is in the approach.

Functional medicine addresses the underlying causes of disease, using a systems-oriented approach and engaging both patient and practitioner in a therapeutic partnership. It is an evolution in the practice of medicine that better addresses the healthcare needs of the 21st century.

The Functional Medicine model is an individualized, patient-centered, science-based approach that empowers patients and practitioners to work together to address the underlying causes of disease and promote optimal wellness. It requires a detailed understanding of each patient’s genetic, biochemical, and lifestyle factors and leverages that data to direct personalized treatment plans that lead to improved patient outcomes.

By addressing root cause, rather than symptoms, practitioners become oriented to identifying the complexity of disease. They may find one condition has many different causes and, likewise, one cause may result in many different conditions. As a result, Functional Medicine treatment targets the specific manifestations of disease in each individual.

Below you can see a typical matrix widely used by Functional Medicine Practitioners to map out a patient before determining treatment.

Preparing Yourself for the Flu Season Naturally

Each winter the influenza virus wreaks havoc on our ability to work and play. Symptoms of the flu include fever, fatigue, muscle aches, headache, runny nose, cough and stomach symptoms like nausea, vomiting and diarrhea. Sometimes a flu virus can come on slowly or it can hit suddenly without much notice. Each year this leads people to wonder how they can prevent themselves and their family from getting the flu. Naturopathic prevention and treatment of the flu virus includes vitamins and minerals, botanical medicine and lifestyle recommendations.

Vitamins and Minerals:

•Vitamin C – Vitamin C can greatly enhance the immune system’s ability to fight infections of many kinds. In controlled trials Vitamin C has been shown to aid in the prevention of influenza, as well as shortening the duration and reducing the severity of infections already contracted.

• Zinc – Zinc plays an important role in maintaining healthy immune function. Low levels of zinc are associated with a decrease in T cell function, a vital white blood cell that helps fight infections.

• Vitamin A – Vitamin A is also associated with T cell function, making it a vital component of a healthy immune system. Vitamin A maintains the integrity of mucus membranes, which are at the front line of our defenses against viral, bacterial, and parasitic infections.

Botanical Medicine:

• Elderberry – Research demonstrates that elderberry extract has particular immune-modulating and antioxidant properties that neutralize the activity of viruses so they can no longer enter the cell and replicate. The berries also contain vitamins A and C, and the flavonoids quercetin, anthocyanin and rutin, all of which boost immune function.

Larch arbinogalactans – Larch arabinogalactans are polysaccharides derived from the wood of the Western larch tree. These polysaccharides stimulate the immune system to fend off infections. Larch arabinogalactans have been studied and shown effective in adults, as well as children, which makes it a great choice for keeping the whole family healthy through the flu season.• Echinacea – Echinacea also has the immune stimulating polysaccharides that give it an important role in naturopathic antiviral treatments. These polysaccharides naturally enhance the body’s resistance to infection.

Lifestyle tips for the prevention and treatment of the flu:

•Sleep – Maintaining a balanced sleep routine is one way to keep our immune system healthy. Adults need 7 to 9 hours of sleep each night to rejuvenate for the next day. Consistent inadequate sleep lowers the body’s defenses needed for fighting viral infections.

• Stress – While stress is a part of everyday life; excessive stress can decrease immune function and make it easier to come down with the flu. Establishing stress management techniques like deep breathing, exercise, yoga or meditation can help ensure that every day stress won’t leave you vulnerable to the flu.

• Diet – A diet rich in fruits, vegetables and quality proteins is a foundation for a healthy immune system. Studies have shown that eating a sugary snack or meal can depress the immune system for several hours, creating a window of time during which it is easier to get the flu. Avoiding excessive sugar can keep the immune system working at the level needed to fend off viral infections, like the flu.

By svitech|January 24th, 2018|blog|0 Comments